業務項目
	トランスジェニックマウスの作製と販売
	実験動物の飼育管理請負（給餌・給水・ケージ交換等）
	動物実験の補助
	動物実験施設の消毒
	小動物（マウス・ラット等）の受託試験業務
	分子生物学受託試験業務（PCR・ウェスタン等）
	蛋白結晶化・構造解析のコンサルタント

医科学部門発表文献

２００５年 [1] Tokimasa, M., Minoura, K., Hiraoka, S., Tomoo, K., Sumida, M., Taniguchi, T. and Ishida, T. (2005) Importance of local structures of second and third repeat fragments of microtubule-binding domain for tau filament formation. FEBS Lett 579, 3481-6. [2] Taniguchi, T., Sumida, M., Hiraoka, S., Tomoo, K., Kakehi, T., Minoura, K., Sugiyama, S., Inaka, K., Ishida, T., Saito, N. and Tanaka, C. (2005) Effects of different anti-tau antibodies on tau fibrillogenesis: RTA-1 and RTA-2 counteract tau aggregation.FEBS Lett 579, 1399-404. [3] Minoura, K., Mizushima, F., Tokimasa, M., Hiraoka, S., Tomoo, K., Sumida, M., Taniguchi, T. and Ishida, T. (2005) Structural evaluation of conformational transition state responsible for self-assembly of tau microtubule-binding domain. Biochem Biophys Res Commun 327, 1100-4. ２００４年 [4] Minoura, K., Yao, T.M., Tomoo, K., Sumida, M., Sasaki, M., Taniguchi, T. and Ishida, T. (2004) Different associational and conformational behaviors between the second and third repeat fragments in the tau microtubule-binding domain. Eur J Biochem 271, 545-52. [5] Hiraoka, S., Yao, T.M., Minoura, K., Tomoo, K., Sumida, M., Taniguchi, T. and Ishida, T. (2004) Conformational transition state is responsible for assembly of microtubule-binding domain of tau protein. Biochem Biophys Res Commun 315, 659-63. ２００３年 [6] Yao, T.M., Tomoo, K., Ishida, T., Hasegawa, H., Sasaki, M. and Taniguchi, T. (2003) Aggregation analysis of the microtubule binding domain in tau protein by spectroscopic methods.J Biochem (Tokyo) 134, 91-9. [7] Tomoo, K., Shen, X., Okabe, K., Nozoe, Y., Fukuhara, S., Morino, S., Sasaki, M., Taniguchi, T., Miyagawa, H., Kitamura, K., Miura, K. and Ishida, T. (2003) Structural features of human initiation factor 4E, studied by X-ray crystal analyses and molecular dynamics simulations. J Mol Biol 328, 365-83.